These results highlight the potential of integrated sustainable curricula and climate change sensitivity to enhance climate change capabilities. Although ANN performed comparably with multiple linear regression, fsQCA showed that the presence of any single condition (integrated sustainable curricula, climate change sensitivity, or generative AI tool usage) was sufficient to explain high levels of climate change capabilities. To the authors’ knowledge, this study is the first to measure the moderated mediation among integrated sustainable curricula, generative AI tools, and climate change sensitivity in relation to climate change capabilities within Global South and North contexts, using PLS-SEM, fsQCA, and ANN analytics. Our study also provides implications for practitioners, such as university management, curriculum policymakers and teachers, along with future research directions.