With the development of online education, how to effectively use big data technology to meet personalized learning needs has become an important issue. This study takes several online entrepreneurship training courses as the research object, and uses information mining technology to extract and analyze students’ behavioral data during course participation, including data on study time, interaction frequency, assessment results, etc. Through machine learning algorithms and association rule mining, the research revealed the main factors that affect students’ learning effects and entrepreneurial success, and designed targeted teaching strategies, such as dynamically adjusting learning content, providing personalized feedback, optimizing learning paths, etc.