There are important steps to be taken in higher education as we prepare for the deep societywide changes that will take place in the next five to 10 years. Almost certainly the fall 2025 semester, or shortly thereafter, we will see the expanding use of generative AI as instructors. We already rely on apps to help us construct course syllabi, learning outcomes, grading rubrics and much more. AI conducts discussion boards, serves as tutors such as Khanmigo and orchestrates adaptive learning. The advent of synthetic instructors, perhaps supervised at first by human “master instructors,” will create a notable milestone along the way of AI progress in higher education. The premise of our system of colleges and universities is founded on teaching and learning for humans. If the workforce of the educated and skilled drops by nearly half, there would seem to be implications for our institutions.