UN Women’s Second Chance Education (SCE) Programme (2018–2023) provides women who have missed out on education with a second chance to access learning and training opportunities and find pathways to personal and economic empowerment. E-learning has been a core component of SCE from the start, offered either in tandem with face-to-face training in the hubs and other locations through a blended learning approach or through a wholly online modality. Thousands of women have been introduced to e-learning for the first time, in no small part due to the localized and creative solutions to the barriers facing women learning online: lack of digital devices, connectivity and skills; lack of confidence; and lack of relevant, relatable and contextualized content. This brief draws on the experiences across all six countries and outlines the top 10 lessons learned.